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However when glutathione becomes depleted it triggers a destructive inflammatory process

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Despite the complexities and the many factors involved in diseases of iron metabolism and iron toxicity, the identification of the mechanisms involved, and the use of appropriate diagnostic criteria could provide efficient targeted therapies and the complete elimination of iron toxicity, as shown in the case of the transition of thalassaemia from a fatal to a chronic disease [39,88,295,296,297,298]